武汉光化学技术研究院

获得国家自然科学基金项目、国家重点研发计划项目、武汉市科技创新项目、武汉光化学技术研究院中试孵化项目支持。

1. Xiaoliang Guo,# Qinqin Jiang,# Zengru Li, Cai Cheng, Yu Feng, Yanlin He, Lingzi Zuo, Wei Ding, Delin Zhang, Lingling Feng*. Crystal structural analysis and characterization for MlrC enzyme of Sphingomonas sp. ACM-3962 involved in linearized microcystin degradation. Chemosphere. 2023, 317:137866. DOI: 10.1016/j. chemosphere.2023.137866 (SCI IF 8.943) 2. Xiaoliang Guo,# Zengru Li,# Qinqin Jiang,# Cai Cheng, Yu Feng, Yanlin He, Lingzi Zuo, Li Rao, Wei Ding, and Lingling Feng*. Structural insight into substrate binding mode and catalytic mechanism for MlrC enzyme of Sphingomonas sp. ACM-3962 involved in linearized microcystin biodegradation. Frontiers in Microbiology. 2023, 14:1057264. DOI: 10.3389/fmicb.2023.1057264 (SCI IF 6.064) 3. Huang Shi, Zuo Lingzi, Cheng Guolian, He Yanlin, Zhang Liexiong, Han Qiang, Feng Lingling*. Design, synthesis and mechanism research of novel algicide based on bioactive fragments synthesis strategy. Pestic Biochem Physiol. 2023, 191:105344. DOI: 10.1016/j.pestbp.2023.105344 (SCI IF 4.966) 4. Hong-Lin Liu,# Cai Cheng,# Ling-Zi Zuo,# Ming-Yue Yan, Yan-Lin He, Shi Huang, Ming-Jing Ke, Xiao-Liang Guo, Yu Feng, Hai-Feng Qian* and Ling-Ling Feng.* Strain-boosted hyperoxic graphene oxide efficiently loading and improving performances of microcystinase. iScience, 2022, 25, 104611, 1-22. DOI:10.1016/j.isci. 2022.104611. (SCI IF 6.107) 5. Yuling Han, Lei Tan, Ting Zhou, Liuliu Yang, Lucia Carrau, Lauretta A. Lacko,1 Mohsan Saeed, Jiajun Zhu, Zeping Zhao, Benjamin E. Nilsson-Payant, Filipe Tenorio Lira Neto, Clare Cahir, Alice Maria Giani, Jin Chou Chai, Yang Li, Xue Dong, Dorota Moroziewicz, The NYSCF Global Stem Cell Array Team, Daniel Paull, Tuo Zhang, Soyeon Koo, Christina Tan, Ron Danziger, Qian Ba, Lingling Feng, Zhengming Chen, Aaron Zhong, Gilbert J. Wise, Jenny Z. Xiang, Hui Wang, Robert E. Schwartz, Benjamin R. tenOever, Scott A. Noggle, Charles M. Rice, Qibin Qi, Todd Evans, and Shuibing Chen*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell, 2022, 29, 1475–1490. https://doi.org/10.1016/j.stem.2022.09.008 (SCI IF 25.269) 6. Mingjing Ke, Lan Feng, Shi Huang, Tao Lu, Zhitao Yu, Yaohui Yang, Hang Hu, Willie J.G.M. Peijnenburg, Lingling Feng,* and Haifeng Qian*. Development of a Potentially New Algaecide for Controlling Harmful Cyanobacteria Blooms Which is Ecologically Safe and Selective. J. Agric. Food Chem., 2022, 70, 10134-10143 https://doi.org/10.1021/acs.jafc.2c02489 (SCI IF 5.895) 7. Honglin Liu,# Xiaoliang Guo,# Lei Liu, Mingyue Yan, Jiahui Li, Shuyan Hou, Jian Wan and Lingling Feng*. Simultaneous microcystin degradation and microcystis inhibition with single enzyme microcystinase A. Environmental Science & Technology, 2020, 54, 8811-8820. https://doi.org/10.1021/acs.est.0c02155. (SCI IF 11.357) 8. Yunyuan Huang,# Yixiang Xu,# Rongrong Song,# Shuaishuai Ni,# Jiaqi Liu, Yanhong Xu, Yanliang Ren,* Li Rao, Yingjie Wang, Lin Wei, Lingling Feng, Chen Su, Chao Peng, Jian Li,* and Jian Wan* Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction. Journal of Medicinal Chemistry, 2020, 63(11), 6238-3247. DOI: 10.1021/acs.jmedchem.0c00699. (SCI IF 8.039) 9. Xiao Geng, Can Wang, Chun Huang, Yang Bao, Peng Zhao, You Zhou, Yandong Wu, Lingling Feng* and Anxin Wu*. Employing TosMIC as a C1N1 “Two-Atom Synthon” in imidazole synthesis by neighboring group assistance strategy. Organic Letters, 2020, 22,140-144. DOI: 10.1021/acs.orglett.9b04060. (SCI IF 6.072) 10. Jiangtao Feng, # HaifengHe, # YuanZhou, Xiaoliang Guo, Honglin Liu, Meng Cai, Fang Wang, Lingling Feng⁎ and Hongwu He.⁎ Design, synthesis and biological evaluation of novel inhibitors against cyanobacterial pyruvate dehydrogenase multienzyme complex E1. Bioorganic & Medicinal Chemistry, 2019, 27, 2413-2420. DOI: 10.1016/j.bmc.2019.01.021. (SCI IF 3.461) 11. Jiangtao Feng#, Haifeng He#, Yuan Zhou, Meng Cai, Hao Peng, Honglin Liu, Lei Liu, Lingling Feng⁎ and Hongwu He⁎. Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1, Bioorganic & Medicinal Chemistry, 2019, 27: 115159. (SCI IF 3.641) 12. Lingling Feng, Brandoch Cook, SuYi Tsai, Ting Zhou, Brooke LaFlamme, Todd Evans* and Shuibing Chen*. Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation. Cell Reports, 2016, 15, 2063-2075. DOI: 10.1016/j.celrep.2016.04.066. (SCI IF 9.995) 13. Xinya Han,# Yunyuan Huang,# Rui Zhang,# San Xiao, Shuaihuan Zhu, Nian Qin, Zongqin Hong, LinWei, Jiangtao Feng, Yanliang Ren, Lingling Feng* and Jian Wan*. New insight into the binding modes of TNP-AMP to human liver fructose-1,6-bisphosphatase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016,165, 155-160. DOI: 10.1016/j.saa.2016.04.002. (SCI IF 4.831) 14. Haifeng He,# Jiangtao Feng,# Junbo He, Qin Xia, Yanliang Ren, Fang Wang, Hao Peng, Hongwu He* and Lingling Feng* Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1 inhibitors. RSC Advances, 2016, 6, 4310-4320. DOI: 10.1039/C5RA22573F. (SCI IF 4.036) 15. Haifeng He,# Wei Wang,# Yuan Zhou, Qin Xia, Yanliang Ren, Jiangtao Feng, Hao Peng, Hongwu He* and Lingling Feng* Rational design, synthesis and biological evaluation of 1,3,4-oxadiazole pyrimidine derivatives as novel pyruvate dehydrogenase complex E1 inhibitors. Bioorganic & Medicinal Chemistry, 2016, 24, 1879-1888. DOI: 10.1016/j.bmc.2016.03.011. (SCI IF 3.461) 16. Lingling Feng, Junbo He, Haifeng He, Lulu Zhao, Lingfu Deng, Li Zhang, Lin Zhang, Yanliang Ren, Jian Wan*, and Hongwu He*. The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors against pyruvate dehydrogenase multienzyme complex E1 from Escherichia coli. Organic Biomolecular Chemistry 2014, 12 (44), 8911-8918. DOI: 10.1039/C4OB01347F. (SCI IF 3.890) 17. Lingling Feng, Yao Sun, Hui Deng, Ding Li, Jian Wan, Xiaofeng Wang, Weiwei Wang, Xun Liao, Yanliang Ren, Jian Wan* and Xiaopeng Hu*. Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803. FEBS Journal 2014, 281(3), 916-926. DOI: 10.1111/febs.12657. (SCI IF 5.622) 18.Yao Sun, Rui Zhang, Ding Li, Lingling Feng*, Di Wu, Lina Feng, Peipei Huang, Yanliang Ren, JiangTao Feng, San Xiao, Jian Wan*. Pharmacophore-based virtual screening and experimental validation of novel inhibitors against cyanobacterial fructose-1, 6-/sedoheptulose-1, 7-bisphosphatase. Journal of Chemical Information and Modeling, 2014, 54 (3), 894-901. DOI: 10.1021/ci4007529. (SCI IF 6.162), 19. Junbo He1, Lingling Feng1, Jing Li, Ruijuan Tao, Yanliang Ren, Jian Wan*, Hongwu He*. Design, synthesis and molecular modeling of novel N-acylhydrazone derivatives as pyruvate dehydrogenase complex E1 inhibitors. Bioorganic & Medicinal Chemistry, 2014, 22, 89-94. DOI: 10.1016/j.bmc. 2013.11.051. (SCI IF 3.461) 20. Qidong Tu#, Ding Li#, Yao Sun#, Xinya Han, Fan Yi, Yibamu Sha, Yanliang Ren, Mingwu Ding, Lingling Feng* and Jian Wan*. Design and syntheses of novel N0-((4-oxo-4H-chromen-3-yl) methylene) benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7- bisphosphatase. Bioorganic & Medicinal Chemistry, 2013, 21, 2826-2831. DOI: 10.1016/j.bmc.2013.04.003. (SCI IF 3.461) 21. Yao Sun, Xun Liao, Ding Li, Lingling Feng*, Xiaofeng Wang, Jing Jin, FanYi, Li Zhou, and Jian Wan*. Study on the interaction between cyanobacteria FBP/SBPase and metal ions. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012, 89, 337-344. DOI: 10.1016/j.saa.2011.12.014. (SCI IF 4.831) 22. Junbo He,# Lingling Feng,# Jing Li, Ruijuan Tao, Fang Wang, Xun Liao, Qiushuang Sun, Qingwu Long, Yanliang Ren, Jian Wan*, and Hongwu He*. Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1. Bioorganic & Medicinal Chemistry, 2012, 20, 1665–1670. DOI: 10.1016/j.bmc.2012.01.019. (SCI IF 3.461) 23. Pengna Li, Lizhi Zhang*, Weiwei Wang, Jiali Su, and Lingling Feng*. Rapid catalytic microwave method to damage microcystis aeruginosa with FeCl3-loaded active carbon. Environmental Science & Technology, 2011, 45, 4521-4526. DOI: 10.1021/es200057g. (SCI IF 11.357) 24. Lingling Feng*, Li Zhou, Yao Sun, Jie Gui, Xiaofeng Wang, Ping Wu, Jian Wan*, Yanliang Ren, Shengxiang Qiu, Xiaoyi Wei, and Jun Li. Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry, 2011, 19, 3512 - 3519. DOI: 10.1016/j.bmc.2011.04.019. (SCI IF 3.461) 25. Qingye Zhang,# Ding Li,# Pei Wei, Jie Zhang, Jian Wan,* Yangliang Ren, Zhigang Chen, Deli Liu, Ziniu Yu and Lingling Feng*. Structure-Based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14r-Demethylase from Penicillium digitatum. Journal of Chemical Information and Modeling, 2010, 50, 317-325. DOI: 10.1021/ci900425t. (SCI IF 6.162)